On the mechanism of protein fold-switchi
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Margaret M. Stratton; Stewart N. Loh
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Article
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2010
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John Wiley and Sons
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English
β 375 KB
## Abstract Alternate frame folding (AFF) is a mechanism by which conformational change can be engineered into a protein. The protein structure switches from the wildβtype fold (__N__) to a circularlyβpermuted fold (__N__β²), or vice versa, in response to a signaling event such as ligand binding. De