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The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

✍ Scribed by Catherine Martin; Georgina Berridge; Prakash Mistry; Christopher Higgins; Peter Charlton; Richard Callaghan


Book ID
110004548
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
236 KB
Volume
128
Category
Article
ISSN
0007-1188

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P-glycoprotein (P-gp) is a multidrug transporter responsible for resistance to anticancer chemotherapy and physiologically involved in absorption, distribution, and excretion of a large number of hydrophobic xenobiotics. P-gp exhibits both an ATPase activity correlated with its drug transport functi