The molecular genetics of gastroenteropancreatic neuroendocrine tumors
β Scribed by Michelle N. Zikusoka; Mark Kidd; Geeta Eick; Igor Latich; Irvin M. Modlin
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 361 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0008-543X
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## Background: Recent classifications identify four categories of neuroendocrine (ne) tumors of the lung: low grade typical carcinoid (tc), intermediate grade atypical carcinoid (ac), and high grade large cell neuroendocrine carcinoma (lc-nec) and small cell lung carcinoma (sclc). ## Methods: The
Neuron-specific enolase (NSE) was studied by immunohistochemistry and radioimmunoassay in ten gastroenteropancreatic (GEP) neuroendocrine tumors. Tissue and serum levels of NSE from the same patients were also analyzed. In all cases, NSE was localized by immunohistochemistry as diffuse cytoplasmic s
## Abstract Little is known about the molecular pathogenesis of neuroendocrine tumors (NET) of the gastroβenteroβpancreatic (GEP) system. We analyzed genetic and epigenetic alterations as well as the CpG island methylator phenotype (CIMP). The study comprised 118 wellβdifferentiated foreβ and midβg