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The molecular dynamics of cholesterol in bilayer membranes: A deuterium NMR study

✍ Scribed by Michael G. Taylor; Toshiyuki Akiyama; Ian C.P. Smith

Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
622 KB
Volume
29
Category
Article
ISSN
0009-3084

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✦ Synopsis

The 2H-NMR spectra of selectively deuterated cholesterol, intercalated in egg phosphatidylcholine, were examined. The orientation of the axis of motional averaging was calculated using the observed quadrupole splittings and the atomic coordinates. With the known orientation of the rotation axis, quadrupole splittings observed for deuterium labels on cholesterol can be related to the molecular order parameter of the sterol. In addition, knowledge of the axis orientation allows prediction of the magnitudes of quadrupole splittings for deuterium at other positions, which is useful in the choice of labelling for particular applications. Finally, preliminary relaxation time measurements yield information on the rates of anisotropic motion of cholesterol in bilayer membranes.

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