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The Molecular Basis of α-Thalassemia: A Model for Understanding Human Molecular Genetics

✍ Scribed by Higgs, Douglas R.; Gibbons, Richard J.

Book ID
121194103
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
457 KB
Volume
24
Category
Article
ISSN
0889-8588

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✍ A. N. Başak; H. Özçelik; A. Özer; A. Tolun; M. Aksoy; L. Ağaoğlu; F. Ridolfi; L. 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 471 KB

By using oligonucleotide hybridization, restriction endonuclease analysis and direct sequencing of amplified genomic DNA, we have been able to characterize 18 different mutations in the beta-globin genes of 161 beta-thalassemia homozygotes and 107 beta-thalassemia heterozygotes from Turkey (429 beta