The Molecular Basis of Substrate Channeling

✍ Scribed by Miles, E. W.

• Book ID: 111677958
• Publisher: The American Society for Biochemistry and Molecular Biology
• Year: 1999
• Tongue: English
• Weight: 649 KB
• Volume: 274
• Category: Article
• ISSN: 0021-9258
• DOI: 10.1074/jbc.274.18.12193

✦ Synopsis

1

The abbreviations used are: CPS, carbamoyl-phosphate synthase; GPATase, glutamine phosphoribosylpyrophosphate amidotransferase; DHFR, dihydrofolate reductase; TS, thymidylate synthase; PRPP, phosphoribopyrophosphate.

2 We will not consider enzymes in which the intermediate is covalently bound (e.g. pyruvate dehydrogenase and ␣-ketoglutarate dehydrogenase). 3 We use the hyphen to indicate that two different catalytic domains (e.g. ␣ and ␤) are located on a single polypeptide chain in a bifunctional or multifunctional enzyme.