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The Molecular Basis of Self-Association of Antibodies to IgG (Rheumatoid Factors) in Rheumatoid Arthritis

✍ Scribed by Richard M. Pope, David C. Teller and Mart Mannik

Book ID
123651880
Publisher
National Academy of Sciences
Year
1974
Tongue
English
Weight
881 KB
Volume
71
Category
Article
ISSN
0027-8424

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Susceptibility to rheumatoid arthritis (RA) maps to residues QKRAA/QRRAA in the third hypervariable region of the HLA DRI31 chain. Peptides from the same area of MHC class II molecules are able to modulate the T-cell repertoire by deleting self-reactive T-cells. The Epstein Barr virus glycoprotein g