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The molecular and clinical rationale of extracorporeal photochemotherapy in autoimmune diseases, malignancies and transplantation

✍ Scribed by Peter Szodoray; Gabor Papp; Britt Nakken; Mariann Harangi; Margit Zeher


Book ID
113482256
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
290 KB
Volume
9
Category
Article
ISSN
1568-9972

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✍ F. P. Gasparro; B. Liao; P. J. Foley; X. M. Wang; J. Madison McNiff πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 155 KB

Photochemotherapy employing 8-methoxypsoralen and ultraviolet radiation (PUVA) is widely used in the treatment of psoriasis. The photoactivation of psoralens in skin cells leads to DNA photoadduct formation which may be responsible for the efficacy of PUVA. Subsequent mutations may lead to the incre