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The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia

✍ Scribed by Whitman, S P; Caligiuri, M A; Maharry, K; Radmacher, M D; Kohlschmidt, J; Becker, H; Mrózek, K; Wu, Y-Z; Schwind, S; Metzeler, K H; Mendler, J H; Wen, J; Baer, M R; Powell, B L; Carter, T H; Kolitz, J E; Wetzler, M; Carroll, A J; Larson, R A; Marcucci, G; Bloomfield, C D

Book ID: 111644069
Publisher: Nature Publishing Group
Year: 2012
Tongue: English
Weight: 185 KB
Volume: 26
Category: Article
ISSN: 0887-6924
DOI: 10.1038/leu.2012.34

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PURPOSE: To evaluate the incidence and clinical significance of partial tandem duplications (PTDs) of the mixed lineage leukemia (MLL) gene in a large series of newly diagnosed adult patients (16 to 60 years old) with acute myeloid leukemia (AML) intensively treated within the multicenter treatment