The mitotic window of opportunity for plasmid DNA delivery
β Scribed by Park, Kinam
- Book ID
- 121704937
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 124 KB
- Volume
- 179
- Category
- Article
- ISSN
- 0168-3659
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Successful gene therapy depends on the development of efficient delivery systems. Although pDNA and ODN are novel candidates for nonviral gene therapy, their clinical applications are generally limited owing to their rapid degradation by nucleases in serum and rapid clearance. A great deal of effort
## Abstract A nonβtoxic and efficient gene carrier is one requirement for clinical gene therapy. In this study, amphiphilic peptides composed of arginines and valines were synthesized and characterized as plasmid DNA (pDNA) carriers. The peptides have a cationic region containing 1β4 arginines and