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The mitochondrial antioxidant defence system and its response to oxidative stress

✍ Scribed by Thierry Rabilloud; Manfred Heller; Maria-Pia Rigobello; Alberto Bindoli; Ruedi Aebersold; Joël Lunardi

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
113 KB
Volume
1
Category
Article
ISSN
1615-9853

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✦ Synopsis

The mitochondrial antioxidant defence system and its response to oxidative stress

The antioxidant systems of mitochondria are not well known. Using a proteomicsbased approach, we defined these mitochondrial antioxidant systems and analyzed their response to oxidative stress. It appears that the major mitochondrial antioxidant system is made of manganese superoxide dismutase on the one hand, and of peroxiredoxin III, mitochondrial thioredoxin and mitochondrial thioredoxin reductase on the other hand. With the exception of thioredoxin reductase, all these proteins are induced by oxidative stress. In addition, a change in the peroxiredoxin III pattern can also be observed.

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