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The Mitochondria as Biosensors for the Monitoring of Detergent Compounds in Solution

✍ Scribed by Marcantonio Bragadin; Sabrina Manente; Rossano Piazza; Guido Scutari


Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
47 KB
Volume
292
Category
Article
ISSN
0003-2697

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✦ Synopsis


Immobilization is an important step in the development of both biosensors and binding assays, but traditional immobilization methods have disadvantages in terms of retention of bioactivity as well as limited 307 NOTES & TIPS


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## Abstract Previously mildronate, an aza‐butyrobetaine derivative, was shown to be a cytoprotective drug, through its mechanism of action of inhibition of carnitine palmitoyltransferase‐1, thus protecting mitochondria from long‐chain fatty acid accumulation and subsequent damage. Recently in an az