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The microsomal metabolism of some analogues of cyclophosphamide: 4-methylcyclophosphamide and 6-methylcyclophosphamide

✍ Scribed by Peter J. Cox; Peter B. Farmer; Michael Jarman


Book ID
115772554
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
948 KB
Volume
24
Category
Article
ISSN
0006-2952

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Observations on the mechanism of hydroxy
✍ T. A. Connors; P. J. Cox; P. B. Farmer; A. B. Foster; M. Jarman; J. K. Macleod πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 600 KB

The metabolism of cyclophosphamide-44, (2-[bis(2-chloroethyI)amino]-tetrahydro-4,4-dideuterio-2H-1,3,2-oxazaphosphorine 2-oxide), was studied. The first detectable metabolite was a hydroxy derivative which was trapped with ethanol. Mass spectrometry of the resulting two ethowy derivatives and of the