The MH1 Domains of Smad2 and Smad3 Are Involved in the Regulation of the ALK7 Signals
โ Scribed by Rie Watanabe; Yuichiro Yamada; Yu Ihara; Yoshimichi Someya; Akira Kubota; Shinji Kagimoto; Akira Kuroe; Toshio Iwakura; Zhen-Ping Shen; Akari Inada; Tetsuya Adachi; Nobuhiro Ban; Kazumasa Miyawaki; Yasuhiro Sunaga; Kinsuke Tsuda; Yutaka Seino
- Book ID
- 115581572
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 166 KB
- Volume
- 254
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Background In endothelial cells (EC), transforming growth factor-ฮฒ (TGF-ฮฒ) can bind to and transduce signals through ALK1 and ALK5. The TGF-ฮฒ/ALK5 and TGF-ฮฒ/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-ฮฒ signaling is an important
## Abstract Both Bleomycin and TGFโฮฒ1 increase the transcription of the __COL1A1__ gene. Bleomycin acts through TGFโฮฒ1. Bleomycin stimulates the COL1A1 promoter through the distal TGFโฮฒ response element by intracellular and extracellular signaling. As demonstrated in this manuscript, Bleomycin's in