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The method of minimization for allocation to clinical trials: a review

✍ Scribed by Neil W Scott; Gladys C McPherson; Craig R Ramsay; Marion K Campbell

Book ID: 114186967
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 84 KB
Volume: 23
Category: Article
ISSN: 0197-2456
DOI: 10.1016/s0197-2456(02)00242-8

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Minimum likelihood allocation (MLA) is a new method for sequentially assigning subjects to treatment groups in a clinical trial. Its aim is to balance the trial, that is, to prevent various treatment groups from containing subjects who have much better or much worse prognoses than the average. The o