The metabolism of N-hydroxyurethane in relation to its carcinogenic action: Conversion into urethane and an N-hydroxyurethane glucuronide

The carcinogenic action and metabolism o

The carcinogenic action and metabolism of N-hydroxyurethane in newborn mice

✍ L. Boiato; S. S. Mirvish; I. Berenblum 📂 Article 📅 1966 🏛 John Wiley and Sons 🌐 French ⚖ 362 KB

Ten weekly intraperitoneal injections, starting at birth, of N-hydroxyurethane into C57BL/6 mice, produced thymic Iymphosarcomas in 44 per cent and lung adenomas in 78 per cent of survivors. Similar injections of urethane produced lymphosarcomas in 39 per cent and lung adenomas in 75 per cent of sur