The membrane attack complex of complement induces caspase activation and apoptosis
β Scribed by Alma J. Nauta; Mohamed R. Daha; Odette Tijsma; Bob van de Water; Francesco Tedesco; Anja Roos
- Book ID
- 101378841
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 160 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
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## Abstract The membranolytic C5bβ9 complement membrane attack complex (MAC) is assembled after activation of either the classic or the alternative complement pathway. The quaternary configuration of the MAC macromolecule presents neoantigenic determinants not present on precursor molecules. Conseq
Recent studies on the functional activities of the membrane attack complex of complement, C5b-9, are reviewed. A new speculative hypothesis has been advanced to account for the ability of complement to mediate lysis of various targets. This hypothesis has three major elements: 1) that the membrane a