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The mechanism of the localization of67Gallium citrate in experimental abscesses

โœ Scribed by Peter A. G. Hammersley; David M. Taylor

Publisher
Springer
Year
1979
Tongue
English
Weight
385 KB
Volume
4
Category
Article
ISSN
0340-6997

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โœฆ Synopsis

67Ga accumulation in turpentine-induced abscesses, from 5 h to 20 days old, in the rat has been investigated, and the results indicate that this is dependent on polymorphonuclear leukocyte (PMN) infiltration of the inflamed site. 67Ga concentration 24 h after injection correlates well with the activities of the lysosomal enzymes, aryl sulphatase and beta-glucuronidase, P less than 0.001, and with the DNA content of the tissue. There is no direct relationship with the rate of DNA synthesis. The mechanism of lysosomal incorporation into PMNs is consistent with the factors involved in 67Ga uptake into tumours and normal tissues.

๐Ÿ“œ SIMILAR VOLUMES

The role of lysosomal enzyme activity in
The role of lysosomal enzyme activity in the localization of67gallium citrate
โœ Peter A. G. Hammersley; David M. Taylor ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› Springer ๐ŸŒ English โš– 730 KB

The distribution of 67Ga citrate at 24 h post injection has been studied in the normal tissues of the mouse, rat and dog; 13 transplantable mouse tumours and 7 rat tumours have also been examined. The total activities of four lysosomal enzymes, aryl sulphatase, beta-glucuronidase, acid phosphatase a