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The mechanism of the increase in mitochondrial proton permeability induced by thyroid hormones

โœ Scribed by Martin D. BRAND; Dietmar STEVERDING; Bernhard KADENBACH; Patricia M. STEVENSON; Roderick P. HAFNER


Book ID
115129362
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
798 KB
Volume
206
Category
Article
ISSN
1432-1327

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Contribution of increased mitochondrial
โœ Aaron M. Byrne; John J. Lemasters; Anna-Liisa Nieminen ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 356 KB

Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc