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The Mechanism of T Cell Mediated Cytotoxicity. III. Changes in Target Cell Susceptibility during the Cell Cycle

✍ Scribed by Sanderson, C. J.; Thomas, J. A.

Book ID
120142744
Publisher
The Royal Society
Year
1976
Tongue
English
Weight
570 KB
Volume
194
Category
Article
ISSN
0080-4649

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Cytotoxic T lymphocytes secrete a pore-forming cytolysin, perforin, that damages membranes of target cells. They also ligate Fas receptors on target cells and provoke apoptotic death. A20 (B lymphoma) and P815 (mastocytoma) cell lines were examined for their susceptibility to perforin-mediated lysis