The mechanism of replication of hepatitis B virus: Evidence of asymmetric replication of the two DNA strands
β Scribed by M. J. F. Fowler; Dr. J. Monjardino; K. N. Tsiquaye; A. J. Zuckerman; H. C. Thomas
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 572 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0146-6615
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β¦ Synopsis
In this study we have characterised the DNA replicative intermediates of hepatitis B virus and have shown that HBV-DNA replication is asymmetric. This pattern of HBV replication is similar to that reported for the related duck hepatitis virus (DHBV) and suggests the involvement of a similar reverse transcription process in HBV-DNA replication.
π SIMILAR VOLUMES
The carbocyclic analog of deoxyguanosine inhibits hepatitis B virus replication by greater than 95% in the hepatitis B vim-producing cell line (2.2.15) as monitored by decreases of secreted hepatitis B virus DNA, hepatitis B virus polymerase activity and intracellular episomal hepatitis B virus DNA.
## VICENTE CARRENO The presence of hepatitis B virus DNA was studied in peripheral blood mononuclear cell samples from 259 HBsAg carriers (229 anti-hepatitis delta negative, 30 anti-hepatitis delta positive), 16 anti-HBc-positive HBsAg-negative patients and 30 patients without hepatitis B virus ma