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The Mechanism of Ras GTPase Activation by Neurofibromin †

✍ Scribed by Phillips, Robert A.; Hunter, Jackie L.; Eccleston, John F.; Webb, Martin R.

Book ID
127044390
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
128 KB
Volume
42
Category
Article
ISSN
0006-2960

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✍ Sherry Agellon; James C. Stone 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 766 KB

Wild-type ras has GTPase activity, and this activity is accelerated substantially by GTPase-activating proteins (GAPs). Oncogenic ras species have an abnormally low intrinsic GTPase activity, and this activity is insensitive to GAPs. We confirmed that the anti-ras monoclonal antibody Y13-238 inhibit