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The Mechanism of Orotidine 5‘-Monophosphate Decarboxylase: Catalysis by Destabilization of the Substrate †

✍ Scribed by Feng, Wan Yong; Austin, Travis J.; Chew, Frank; Gronert, Scott; Wu, Weiming

Book ID
127171907
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
60 KB
Volume
39
Category
Article
ISSN
0006-2960

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✍ Jeffrey A. Smiley; Kelly M. Hay; Bruce S. Levison 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 218 KB

A potential alternate substrate for orotidine-5Ј-monophosphate decarboxylase, 2-thio-orotidine-5Ј-monophosphate, was synthesized enzymatically and purified by a modification of a previous account (K. Shostak, and M. E. Jones 1992, Biochemistry 31, 12155-12161). Characterization of the product was co