The mechanism of iron exchange between synthetic iron chelators and rabbit reticulocytes
β Scribed by Deeporn Hemmaplardh; E.H. Morgan
- Book ID
- 115722429
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 855 KB
- Volume
- 373
- Category
- Article
- ISSN
- 0005-2736
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The Belgrade rat has a hypochromic, microcytic anemia inherited as an autosomal recessive mutation. Although transferrin binds normally to reticulocytes and internalizes normally, iron accumulation into cells and heme is much slower than normal. We have investigated the role of the transferrin cycle
## Abstract Chromatographic methods have been developed for the separation of the three novel biocompatible iron chelators pyridoxal isonicotinoyl hydrazone (PIH), salicylaldehyde isonicotinoyl hydrazone (SIH), and pyridoxal 2βchlorobenzoyl hydrazone (oβ108) from their synthetic precursors and iron
The two stages in the uptake of transferrin by rabbit reticulocytes were investigated using radioiodine-labeled rabbit transferrin and albumin. The first stage of rapid, temperature-insensitive uptake of transferrin was similar to albumin uptake: uptake of both proteins increased linearly with incre