The mechanism of insulin action

✍ Scribed by David B. Sacks

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 462 KB
• Volume: 26
• Category: Article
• ISSN: 0009-9120
• DOI: 10.1016/0009-9120(93)90132-p

✦ Synopsis

DOSCH

the best affinity from a pool of cells originally activated and expanded by dietary ABBOS (11).

However, IDDM is a T cell-mediated disease and it was critical to determine if BSA/ABBOS specific T cells could be detected in IDDM patients. In a collaborative study, now almost completed, of nearly 50 Canadian children with IDDM, essentially all had detectable BSA/ABBOS-sensitized T cells, uniformly specific for the same octamer sequence motif overlapping the N-terminus of ABBOS.

Although impressive in their uniformity, such data can only delineate disease association but not disease cause. Therefore, we and colleagues in North America and Europe, in particular Finland, designed a large clinical trial that will determine if avoidance of cow's milk exposure during the first 9 months of life will prevent IDDM. Newborns of highrisk families (mother, father, or sibling with IDDM) will be randomly assigned in a blind study to a baby formula (ABBOS free or standard), that will be used whenever supplementary feeding is needed instead of breast feeding ( 13). Phase I of this trial is well underway, with pilot studies in Europe (Helsinki) and North America (Hamilton, Ont), and the full study involving nine countries recruiting well over 3000 families is expected to start in early 1994. Because of the long period until overt disease, followup will be 10 years.