The mechanism of hydrolysis of phthalamic and N-phenylphthalamic acid: The spectrophotometric detection of phthalic anhydride as an intermediate

Using mixed anhydrides from amino acids

Using mixed anhydrides from amino acids and isobutyl chloroformate in N-acylations: a case study on the elucidation of mechanism of urethane formation and starting amino acid liberation using carbon dioxide as the probe

✍ Apurva Chaudhary; Michael Girgis; Mahavir Prashad; Bin Hu; Denis Har; Oljan Repi 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 114 KB

A case study on the elucidation of mechanism of urethane by-product formation and starting amino acid liberation during the conventional two-step isobutyl chloroformate mediated N-acylation is described using carbon dioxide offgas as the probe. The main reason for the urethane formation and starting