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The Mechanism of Autoprocessing of the Propeptide of Prosubtilisin E: Intramolecular or Intermolecular Event?

โœ Scribed by Yuyun Li; Masayori Inouye

Book ID
115627547
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
115 KB
Volume
262
Category
Article
ISSN
0022-2836

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The role of tryptophan residues in the autoprocessing of prosubtilisin E
โœ Michio Sone; Liliana Falzon; Masayori Inouye ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 359 KB

Subtilisin E, a serine protease from Bacillus subtilis, requires an N-terminal propeptide for its correct folding. The propeptide is autocleaved and digested by the subtilisin domain upon proper folding. Here we investigated the individual roles of the three Trp residues within the subtilisin domain