✦ LIBER ✦
The mechanism of alloxan toxicity: an indication for alloxan complexes in tissues and alloxan inhibition of 4-acetamido-4′-isothiocyanato-stilbene-2,2′-disulphonic acid (SITS) binding for the liver cell membrane
✍ Scribed by N. Bilić
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 501 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0012-186X
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✦ Synopsis
It is shown that alloxan inhibits binding of SITS to liver cells. This indicates the cell membrane as a site of alloxan action. Alloxan is found to react with tissues to form complexes that are detectable up to 3 hrs after alloxan treatment. On the basis of the present findings, an assumption is made that alloxan inhibits a cell membrane processes by blockade of functionally importnat groups.