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The mechanism involved in the regulation of phospholipase Cγ1 activity in cell migration

✍ Scribed by Piccolo, Enza; Innominato, Pasquale F; Mariggio, Maria A; Maffucci, Tania; Iacobelli, Stefano; Falasca, Marco


Book ID
110066977
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
888 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Phospholipase C‐γ1 (PLCγ1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5‐inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCγ1 in PLCγ1‐mediated cell signaling, we character