✦ LIBER ✦

The mechanism by which dietary AGEs are a risk to human health is via their interaction with RAGE: Arguing against the motion

✍ Scribed by Claus W. Heizmann

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 374 KB
Volume: 51
Category: Article
ISSN: 1613-4125
DOI: 10.1002/mnfr.200600284

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We are interested in the regulation of intracellular calcium and the various diseases associated with an altered regulation of this second messenger. More recently, we also became interested in pathologies involving the Ca2+‐binding S100 proteins and AGEs and their association with the multifunctional Receptor for Advanced Glycation Endproducts (RAGE).

Introduction: http://dx.doi.org/10.1002/mnfr.200700017

Pro arguments: http://dx.doi.org/10.1002/mnfr.200700008

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## Abstract The receptor for advanced glycation endproducts (RAGE) has a well‐substantiated role in cell dysfunction and mechanisms of inflammatory disease. The physiological agonists of RAGE are less certain: S100/calgranulin proteins, high mobility group‐1 protein HMGB1 and other proteins are can