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The MDM2 RING finger is required for cell cycle-dependent regulation of its protein expression

✍ Scribed by Ling Gu; Haoqiang Ying; Hongwu Zheng; Stephen A. Murray; Zhi-Xiong Jim Xiao


Book ID
117105449
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
242 KB
Volume
544
Category
Article
ISSN
0014-5793

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## Abstract The serine/threonine kinase PAK4 regulates cytoskeletal architecture, and controls cell proliferation and survival. In most adult tissues PAK4 is expressed at low levels, but overexpression of PAK4 is associated with uncontrolled proliferation, inappropriate cell survival, and oncogenic