SH3 domain of Bruton's tyrosine kinase c
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Himatkumar V. Patel; Shiou-Ru Tzeng; Chen-Yee Liao; Shi-Han Chen; Jya-Wei Cheng
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Article
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1997
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John Wiley and Sons
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English
β 115 KB
X-linked agammaglobulinemia (XLA), an inherited disease, is caused by mutations in the Bruton's tyrosine kinase (BTK). The absence of functional BTK leads to failure of B-cell differentiation; this incapacitates antibody production in XLA patients, who suffer from recurrent, sometimes lethal, bacter