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The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain

✍ Scribed by Katrin Engel; Kathrin Plath; Matthias Gaestel


Book ID
115928665
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
649 KB
Volume
336
Category
Article
ISSN
0014-5793

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SH3 domain of Bruton's tyrosine kinase c
✍ Himatkumar V. Patel; Shiou-Ru Tzeng; Chen-Yee Liao; Shi-Han Chen; Jya-Wei Cheng πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 115 KB

X-linked agammaglobulinemia (XLA), an inherited disease, is caused by mutations in the Bruton's tyrosine kinase (BTK). The absence of functional BTK leads to failure of B-cell differentiation; this incapacitates antibody production in XLA patients, who suffer from recurrent, sometimes lethal, bacter