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The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor

✍ Scribed by Vergés, Marcel; Luton, Frédéric; Gruber, Carmen; Tiemann, Frank; Reinders, Lorri G.; Huang, Lan; Burlingame, Alma L.; Haft, Carol R.; Mostov, Keith E.

Book ID
109912275
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
513 KB
Volume
6
Category
Article
ISSN
1465-7392

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The polymeric immunoglobulin receptor (pIgR), which is constitutively expressed on the basolateral surface of secretory epithelial cells, mediates external translocation of polymeric IgA and pentameric IgM (collectively called pIg) to exocrine secretions. A high level of synthesis must be maintained