The major role of macrophages and their product tumor necrosis factor α in the induction of arthritis triggered by bacterial DNA containing CpG motifs

Blocking of interferon regulatory factor

Blocking of interferon regulatory factor 1 reduces tumor necrosis factor α–induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein a: Role of the nuclear interferon regulatory factor 1–NF-κB–c-jun complex

✍ Hubert Marotte; Pei-Suen Tsou; Bradley J. Rabquer; Adam J. Pinney; Tatiana Fedor 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 586 KB

## Abstract ## Objective To examine the role of interferon regulatory factor 1 (IRF‐1) in tumor necrosis factor α (TNFα)–induced interleukin‐18 binding protein a (IL‐18BPa) expression in rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods TNFα‐induced IRF‐1 expression was assessed by r