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The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice

✍ Scribed by David Liñares; Paula Mañá; Melinda Goodyear; Anne M. Chow; Chelsea Clavarino; Nicholas D. Huntington; Louise Barnett; Frank Koentgen; Ryo Tomioka; Claude C.A. Bernard; Manuel Freire-Garabal; Hugh H. Reid


Book ID
116613809
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
351 KB
Volume
21
Category
Article
ISSN
0896-8411

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IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that __Mycobacterium tuberculosis__ (__Mtb__) infection in the absence of IL-10 (IL-10^−/−^ mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerat