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The lymphoid chemokine CCL21 costimulates naïve T cell expansion and Th1 polarization of non-regulatory CD4+ T cells

✍ Scribed by Kenneth Flanagan; Dorota Moroziewicz; Heesun Kwak; Heidi Hörig; Howard L. Kaufman


Book ID
113526811
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
604 KB
Volume
231
Category
Article
ISSN
0008-8749

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The role of TGF-g 1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-g 1 has a profound inhibitory effect on naive CD4 + T cell undergoing