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The lymphocyte response to a primary viral neoplasm (MSV) through its entire course in BALB/c mice

✍ Scribed by E. W. Lamon; H. M. Skurzak; Eva Klein

Publisher: John Wiley and Sons
Year: 1972
Tongue: French
Weight: 559 KB
Volume: 10
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910100317

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✦ Synopsis

Abstract

BALB/c mice injected with Moloney sarcoma virus (MSV) developed tumors within 5–8 days which usually completely regressed by day 20–25. Maximal tumor size was around day 15. Lymphocytes from these animals were examined for activity against target cells bearing the Moloney leukemia virus (MLV) associated cell surface antigen at 2‐ to 5‐day intervals for 30 days. Significantly cytotoxic lymphocytes were obtained from animals which had developed no palpable tumor as early as 2 days after infection and from animals in which tumors had completely regressed. The least active lymphocytes were from tumor‐bearing animals. The cytotoxicity of the active lymphocytes was demonstrated to be antigen‐specific by testing also against target cells which were MLV‐negative.

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The humoral antibody response to a primary viral neoplasm (MSV) through its entire course in BALB/c mice

✍ E. W. Lamon; E. Klein; B. Andersson; E. M. Fenyö; H. M. Skurzak 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 659 KB

## Abstract BALB/c mice injected with Moloney sarcoma virus developed within 5–12 days tumors at the site of inoculation which usually completely regressed by day 20–25. Maximal tumor size was reached around day 15. Sera from these animals were examined for complement‐dependent cytotoxic activity a