The lower level of natural anti-thomsen-friedenreich antigen (TFA) agglutinins in sera of patients with gastric cancer related to ABO(H) blood-group phenotype
✍ Scribed by Oleg Kurtenkov; Kersti Klaamas; Ljudmila Miljukhina
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 498 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
The TFA is a tumorassociated, bloodgrouprelated glycosidic precursor structure [Gal(β^1‐3^)GalNAc]. Its expression in carcinomas is accompanied by a decrease of natural TFA antibodies in serum. The relationship between the ABO(H)‐bloodgroup phenotype and natural anti‐TFA immune response in patients with gastric cancer was studied. The level of TFA agglutinins in the sera of patients with gastric cancer and of healthy controls was examined by the hemagglutination of neuraminidasetreated bloodgroup‐O donor erythrocytes. Individuals were classified as weak or strong TFA responders. They were also classified by ABO(H)‐bloodgroup status, age, cancer stage, tumor morphology and level of isohemagglutinins. The proportion of weak TFA responders (WR) in cancer patients was 33, 50, 50 and 20% (for O, A, B and AB blood groups respectively), as compared with 11.7, 14.5, 13.9 and 26.1% for bloodgrouprelated controls. The difference between cancer patients and controls was significant for all blood groups except group AB. Further analysis showed agedependence in bloodgroup‐O and ‐B controls, with a high level of WR in the older group. Bloodgroup‐A cancer patients had the greatest and uniform suppression of the level of TFA agglutinins, irrespective of age, cancer stage or tumor morphology, and lower levels of anti‐B isohemagglutinins. © 1995 Wiley‐Liss, Inc.