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The loss of chemically induced mutations in excision-deficient and -proficient yeast (Saccharomyces cerevisiae)

✍ Scribed by B.J. Kilbey


Book ID
113250838
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
62 KB
Volume
130
Category
Article
ISSN
0165-1161

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr