The locomotor-reducing effects of GABAergic drugs do not depend on the GABAAreceptor

✍ Scribed by Anders Agmo; Magda Giordano

• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 470 KB
• Volume: 87
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00431777

✦ Synopsis

The locomotion-reducing effect of the GABA B agonist baclofen was compared with that of the GABA A agonists, aminopropanesulfonic acid (APSA) and THIP. It was found that baclofen was more potent than the other drugs. After intraventricular injection, baclofen induced almost complete immobility, whereas APSA did not affect locomotor activity. THIP had an intermediate effect. The GABA transaminase inhibitor y-acetylenic GABA (GAG) provoked a dose-dependent reduction of locomotion. Neither the effects of THIP nor those of GAG could be blocked by concurrent administration of bicuculline. The antagonist itself did not affect locomotor activity. It is concluded that the GABA A receptor is not important for the locomotionreducing effects of GABAergic drugs.