The localization of a paralysis toxin in granules and nuclei of prefed femaleRhipicephalus evertsi evertsitick salivary gland cells
✍ Scribed by J. C. Crause; J. A. Verschoor; J. Coetzee; H. C. Hoppe; J. N. Taljaard; R. Gothe; A. W. H. Neitz
- Publisher
- Springer Netherlands
- Year
- 1993
- Tongue
- English
- Weight
- 686 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0168-8162
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✦ Synopsis
A monoclonal antibody directed against a paralysis toxin of Rhipicephalus evertsi evertsi ticks was used to localize the toxin in cytoplasmic granules and, surprisingly, chromatin of the nuclei of cells which resemble the "b" cell type in the saliv,'uy glands of Rhipicephalus appendiculatus, Boophilus microplus and lxodes holocyclus. The association of toxin with chromatin indicates that the toxin may have a regulatory function. Evidence is provided to support the view that the toxin is made up of three identical sub-units, with only the trimeric form being toxic.