The liver as a barrier against antigens in viral hepatitis infection

✍ Scribed by P. R. Lorenz

• Book ID: 104758388
• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 726 KB
• Volume: 65
• Category: Article
• ISSN: 0028-1042
• DOI: 10.1007/bf00401919

✦ Synopsis

of experiments with gametes from different animals), the most powerful cocarcinogen from the group of the phorbol esters irreversibly influenced development even in nanomolar concentrations. Thus, the seaurchin embryo reacted at least as sensitively as the mammalian cells tested so far. These cells were unaffected or only reversibly affected by TPA in that concentration range. The action of TPA on the embryo cells must be a specific one as MeTPA and PDA showed a remarkably lower activity, and like many other tested organic and water-insoluble substances, for example alkaloids [6,7], alcohols [8], anesthetics [6], carcinogens [8,9], pesticides [5], or phenols [6,7] acted in the micromolar range b u t showed no effects in nanomolar concentrations. Since the embryotoxic activity of the three phorbol derivatives tested ran parallel to their cocarcinogenic activity, the hypothesis might be postulated that the wimary mechanisms by which the cocarcinogen acts on mammalian cells and on the embryo cells are (he same or at least very similar. The sea-urchin embryo, therefore, might represent a useful model for elucidating the molecular action of the phorbol esters in the cells.