The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human β-amyloid precursor protein transgenic mice

Twofold overexpression of human ?-amyloi

Twofold overexpression of human ?-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury

✍ Murai, Hisayuki; Pierce, Jean E.S.; Raghupathi, Ramesh; Smith, Douglas H.; Saatm 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB 👁 2 views

By using transgenic mice that overexpress human beta-amyloid precursor proteins (APPs) at levels twofold higher than endogenous APPs, following introduction of the human APP gene in a yeast artificial chromosome (YAC), we examined the effects of controlled cortical impact (CCI) brain injury on neuro