Sidechain biology and the immunogenicity
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Tin K. Mao; Paul A. Davis; Joseph A. Odin; Ross L. Coppel; M. Eric Gershwin
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Article
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2004
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John Wiley and Sons
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English
โ 214 KB
๐ 1 views
The E2 component of mitochondrial pyruvate dehydrogenase complex (PDC-E2) is the immunodominant autoantigen of primary biliary cirrhosis. Whereas lipoylation of PDC-E2 is essential for enzymatic activity and predominates under normal conditions, other biochemical systems exist that also target the l