The levels of serum myoglobin in cardiac patients with elevated creatine kinase-MB and suspected acute myocardial infarction

✍ Scribed by Dr. Hugo Moscoso; Charles R. Kiefer; M. Shyamala; Robert J. Teabeaut; Fred A. Garver

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 448 KB
• Volume: 7
• Category: Article
• ISSN: 0887-8013
• DOI: 10.1002/jcla.1860070208

✦ Synopsis

A monoclonal antibody enzyme immunoinhibition assay was used to quantitate serial serum myoglobin (Mb) levels in 121 patients who had 25% creatine kinase-MB (CK-MB) and suspected acute myocardial infarction (AMI). Serum Mb levels higher than 0.16 pgiml were considered abnormal. In 94% of these patients who were finally diagnosed with AMI, Mb levels were higher than 0.16 pgiml, whereas all 30 normal control blood donors had lower Mb levels. Patients with anterior or inferior wall infarcts had higher Mb levels (a0.64 pgiml) than patients with lateral or subendocardial infarction. Only 68% (821 121) of patients evaluated by elevated CK-MB alone had a final diagnosis of AMI. In contrast, 94% (77/83) of patients who in addition showed elevated Mb had AMI. It is suggested that analysis of Mb levels allows a more accurate diagnosis of AM1 in patients with elevated CK-MB than does reliance on CK-MB values alone.