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The level of the mitochondrial mutation A3243G decreases upon ageing in epithelial cells from individuals with diabetes and deafness

✍ Scribed by Olsson, Charlotta; Johnsen, Elsy; Nilsson, Mats; Wilander, Erik; Syvänen, Ann-Christine; Lagerström-Fermér, Maria


Book ID
110025214
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
106 KB
Volume
9
Category
Article
ISSN
1018-4813

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The mitochondrial mutation A3243G has been shown to be associated with a syndrome of diabetes mellitus and sensorineural hearing loss. Using a solid-phase-based sequencing method we have investigated the relation between the proportion of mutant mitochondrial genomes and the time of disease onset am