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The leukotriene D4 -receptor antagonist zafirlukast attenuates exercise-induced bronchoconstriction in children

โœ Scribed by David S. Pearlman; Nancy K. Ostrom; Edwin A. Bronsky; Catherine M. Bonuccelli; Laura A. Hanby


Book ID
117166875
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
199 KB
Volume
134
Category
Article
ISSN
1097-6833

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SK&F 104353, a selective leukotriene rec
โœ R.R. Osborn; D.W.P. Hay; M.A. Wasserman; T.J. Torphy ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier ๐ŸŒ English โš– 444 KB

The ability of SK&F 104353 to prevent and reverse leukotriene (LT) D4- and antigen (Ag)-induced bronchoconstriction was examined in anesthetized, spontaneously breathing cynomolgus monkeys. Aerosol administration of LTD4 (10 micrograms/ml; 20 breaths) produced a sustained increase in pulmonary resis