The Leu-1 B-cell subpopulation in patients with rheumatoid arthritis
β Scribed by Osamu Taniguchi; Hiroaki Miyajima; Takao Hirano; Masaaki Noguchi; Akira Ueda; Hiroshi Hashimoto; Shun-Ichi Hirose; Ko Okumura
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 773 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0271-9142
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π SIMILAR VOLUMES
We studied the peripheral blood lymphocytes of 22 patients with rheumatoid arthritis (RA) for the presence of a subpopulation of cells which form rosettes with mouse erythrocytes. In normal subjects these cells have been characterised as immature B cells which are non-responsive to pokeweed mitogen.
Objective. We sought to compare the frequencies of precursors producing IgM rheumatoid factors (IgM-RFs) in synovial fluid and peripheral blood B cells from patients with rheumatoid arthritis (RA). Methods. We used limiting-dilution analysis of Epstein-Barr virus-activated B cells from seropositive
Objective. To compare the B cell repertoire of normal individuals and patients with rheumatoid arthritis (RA) and, specifically, to identify precursor B cells with the potential to secrete rheumatoid factor (RF) and to understand the T helper cell requirements for the production of this autoantibody