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The Leu-1 B-cell subpopulation in patients with rheumatoid arthritis

✍ Scribed by Osamu Taniguchi; Hiroaki Miyajima; Takao Hirano; Masaaki Noguchi; Akira Ueda; Hiroshi Hashimoto; Shun-Ichi Hirose; Ko Okumura


Publisher
Springer
Year
1987
Tongue
English
Weight
773 KB
Volume
7
Category
Article
ISSN
0271-9142

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πŸ“œ SIMILAR VOLUMES


B-lymphocyte subpopulation which forms r
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We studied the peripheral blood lymphocytes of 22 patients with rheumatoid arthritis (RA) for the presence of a subpopulation of cells which form rosettes with mouse erythrocytes. In normal subjects these cells have been characterised as immature B cells which are non-responsive to pokeweed mitogen.

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Objective. We sought to compare the frequencies of precursors producing IgM rheumatoid factors (IgM-RFs) in synovial fluid and peripheral blood B cells from patients with rheumatoid arthritis (RA). Methods. We used limiting-dilution analysis of Epstein-Barr virus-activated B cells from seropositive

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Objective. To compare the B cell repertoire of normal individuals and patients with rheumatoid arthritis (RA) and, specifically, to identify precursor B cells with the potential to secrete rheumatoid factor (RF) and to understand the T helper cell requirements for the production of this autoantibody