The largest subunit of the RNA polymerase II of Trypanosoma cruzi lacks the repeats in the carboxy-terminal domain and is encoded by several genes
โ Scribed by Tatiana Flank Ejchel; Marcel Ivan Ramirez; Nancy Vargas; Evania Barbosa Azevedo; Maria Carolina Elias; Bianca Zingales; Sergio Schenkman
- Book ID
- 119604237
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 294 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1383-5769
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Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom
Linker-insertion mutagenesis was used to isolate mutations in the Saccharomyces cerevisiae gene encoding the largest subunit of RNA polymerase II (RPO21, also called RPB1). The mutant rpo21 alleles carried on a plamid were introduced into a haploid yeast strain that conditionally expresses RPO21 fro