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The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

✍ Scribed by Wai-Ping Fung-Leung; Marjorie C. Louie; Andreas Limmer; Pamela S. Ohashi; Karen Ngo; Lei Chen; Kazuhiro Kawai; Elizabeth Lacy; Dennis Y. Loh; Tak W. Mak

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 721 KB
Volume: 23
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830231117

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✍ Sara E. Shepherd; Rui Sun; Stanley G. Nathenson; James M. Sheil 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 671 KB

## Abstract To study the structural basis for specificity and affinity of cytotoxic T lymphocytes for major histocompatibility complex/peptide complexes, we have employed a cytotoxic T lymphocyte (CTL)‐mediated immunoselection approach to obtain H‐2K^b^ structural mutants which are resistant to lys